Transplantation for bone marrow failure: current issues

Transplantation for Congenital Bone Marrow Failure Syndromes

Congenital bone marrow failure syndromes (BMFSs) are relatively rare disorders characterized by aberrant development in one or more hematopoietic lineages. Genetic alterations have now been identified in most of these disorders although the exact role of the molecular defects has yet to be elucidated. Most of these diseases are successfully managed with supportive care, however, treatment refra...

Failure Marrow Transplantation after Engraftment Promotes Engraftment for Secondary Bone Primary Bone Marrow Transplantation

Legal issues in bone marrow transplantation.

The article discusses some of the more common legal issues involved in bone marrow transplantation. These include malpractice claims, testing prospective donors for AIDS, sale of bone marrow, informed consent for both donor and recipient, and questions that arise when the donor is a child.

Hepatic failure after bone marrow transplantation.

The article by Beelen et al’ led us to report a case in which the busulfan plus cyclophosphamide preparative regimen for allogeneic bone marrow transplantation terminated in fatal hepatotoxicity. A 31-year-old man with chronic myelogenous leukemia in first chronic phase was bone marrow transplanted from a one DR mismatched donor. Based on encouraging results obtained by Santos et a12 and Tutsch...

ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA

Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...